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✅ Description:
Indications
Anxiety disorder is treated with alprazolam.
Anxiety alleviation in the short term Anxiety and depression are linked.
Panic disorder, whether or not agoraphobia is present.
Pharmacology
Alprax XR 1 is a triazole analog that belongs to the 1,4-benzodiazepine medication family. It works as an anxiolytic, hypnotic, and anticonvulsant. The Gamma Aminobutyric Acid (GABA)-benzodiazepine receptor complex is thought to be involved in the action of alprazolam. It has a dose-dependent CNS depressive effect, similar to other benzodiazepines, ranging from moderate impairment of task performance to hypnosis.
Dosage & Administration
Treatment should be initiated with a dose of 0.25 to 0.5 mg three times daily. Depending on the response, dose may be increased at intervals of 3 to 4 days in increments of no more than 1 mg/day. The maximum dose should not exceed 4 mg/day. Occasional patients with panic disorder may need as much as 10 mg a day to achieve a successful response and in these cases periodic reassessment and consideration of dosage adjustment is required.
Dosage should be individualized for maximum beneficial effect with the lowest possible dose. If side-effects occur at starting dose, dose may be lowered. When discontinuing therapy, dosage should be reduced gradually by no more than 0.5 mg every three days.
In elderly patients or in patients with advanced liver disease, the usual starting dose is 0.25 mg, two or three times daily and may be gradually increased if needed and tolerated.
Alprazolam 1 mg should be administered once daily, preferably in the morning by patients who are on multiple dosage regimens of Alprazolam 0.25/0.5 mg. The tablets should be taken intact, they should not be chewed, crushed, or broken.
Interaction
Concomitant use of other psychotropic medications, anticonvulsants, antihistaminics, alcohol, and oral contraceptives may exacerbate Alprazolam's CNS-depressant effect.
Side Effects
If side effects do develop, they normally arise at the start of treatment and lessen as the patient continues to take the drug. Drowsiness and light-headedness are the most common adverse effects. Depression, headache, disorientation, dry mouth, constipation, and other adverse effects are possible.
Pregnancy & Lactation
Alprazolam is classified as a pregnancy category D drug, which indicates it should be avoided during pregnancy. Alprazolam, like other benzodiazepines, is thought to be secreted in breast milk. As a result, breastfeeding should be avoided by moms who must take Alprazolam.
Precautions & Warnings
Because Alprazolam can create psychological and physical dependence, increasing the dose or abruptly stopping treatment without seeing a doctor is not recommended. The length of treatment must be decided by the doctors. Patients with hepatic or renal illness, chronic pulmonary insufficiency, or sleep apnea should use alprazolam with care.
Therapeutic Class
Benzodiazepine sedatives
Storage Conditions
Keep the temperature below 30°C and away from light and moisture. Keep out of children's reach.
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